Selected Publications in Molecular Dynamics Simulations

 

Spiriti, J. and C. F. Wong (2024). "Quantitative Prediction of Dissociation Rates of PYK2 Ligands Using Umbrella Sampling and Milestoning." Journal of Chemical Theory and Computation 20(9): 4029-4044.
Rathnayake, S., B. Narayan, R. Elber and C. F. Wong (2023). "Milestoning simulation of ligand dissociation from the glycogen synthase kinase 3β." Proteins: Structure, Function and Bioinformatics 91(2): 209-217.
Spiriti, J., F. Noé and C. F. Wong (2022). "Simulation of ligand dissociation kinetics from the protein kinase PYK2." Journal of Computational Chemistry 43(28): 1911-1922.
Spiriti, J. and C. F. Wong (2021). "Qualitative prediction of ligand dissociation kinetics from focal adhesion kinase using steered molecular dynamics." Life 11(2): 1-19.
Dou, R., K. Chen, G. Chi, J. Luo, C. F. Wong and B. Zhou (2021). "Why heptakis(2,3-di-O-acetyl)-β-cyclodextrin can separate terbutaline enantiomers better than β-cyclodextrin: nonbonding and hydrophobic interactions." Journal of Inclusion Phenomena and Macrocyclic Chemistry 100(3-4): 189-195.
Chen, K., R. Ye, X. Liu, C. F. Wong, S. Xu, J. Luo, X. Gong and B. Zhou (2021). "Why 2,6-di-methyl-β-cyclodextrin can encapsulate OH-substituted naphthalenes better than β-cyclodextrin: Binding pose, non-covalent interaction and solvent effect." Computational and Theoretical Chemistry 1206.
Wong, C. F. (2018). "Steered molecular dynamics simulations for uncovering the molecular mechanisms of drug dissociation and for drug screening: A test on the focal adhesion kinase." Journal of Computational Chemistry 39(19): 1307-1318.
Huang, Z. and C. F. Wong (2012). "A Case Study of Scoring and Rescoring in Peptide Docking." Methods in Molecular Biology 819: 269-293.
Huang, Z. and C. F. Wong (2012). "Simulation reveals two major docking pathways between the hexapeptide GDYMNM and the catalytic domain of the insulin receptor protein kinase." Proteins: Structure, Function and Bioinformatics 80(9): 2275-2286.
Huang, Z. and C. F. Wong (2011). Incorporating Protein Flexibility in Molecular Docking by Molecular Dynamics. Computational Studies of New Materials II: From Ultrafast Processes and Nanostructures to Optoelectronics, Energy Storage and Nanomedicine. T. F. George, D. Jelski, R. R. Letfullin and G. Zhang. Singapore, London, World Scientific: 219-250.
Huang, Z. and C. F. Wong (2009). "Docking flexible peptide to flexible protein by molecular dynamics using two implicit-solvent models: an evaluation in protein kinase and phosphatase systems." J Phys Chem B 113(43): 14343-14354.
Huang, Z. and C. F. Wong (2009). "Conformational selection of protein kinase A revealed by flexible-ligand flexible-protein docking." Journal of Computational Chemistry 30(4): 631-644.
Huang, Z., C. F. Wong and R. A. Wheeler (2008). "Flexible protein-flexible ligand docking with disrupted velocity simulated annealing." Proteins 71(1): 440-454.
Huang, Z. and C. F. Wong (2007). "A mining minima approach to exploring the docking pathways of p-nitrocatechol sulfate to YopH." Biophys J 93(12): 4141-4150.
Wang, C. and C. F. Wong (2006). "Molecular dynamics simulation of laser desorption of a fragment of protein kinase A from two maldi matrices." Journal of Physical Chemistry A 110(16): 5355-5360.
Lu, B., C. F. Wong and J. A. McCammon (2005). "Release of ADP from the catalytic subunit of protein kinase A: A molecular dynamics simulation study." Protein Science 14(1): 159-168.
Wang, Q., C. F. Wong and H. Rabitz (1998). "Simulating energy flow in biomolecules: Application to tuna cytochrome c." Biophysical Journal 75(1): 60-69.
Simonson, T., C. F. Wong and A. T. Brünger (1997). "Classical and quantum simulations of tryptophan in solution." J. Phys. Chem. A 101: 1935-1945.
Zhu, S.-B. and C. F. Wong (1994). "Sensitivity Analysis of a Polarizable Water Model." J. Phys. Chem. 98(17): 4695-4701.
Zhu, S.-B. and C. F. Wong (1993). "Sensitivity Analysis of Water Thermodynamics." J. Chem. Phys. 98(11): 8892-8899.
Zhu, S.-B. and C. F. Wong (1993). "Sensitivity Analysis of Distribution Functions of Liquid Water." J. Chem. Phys. 99(11): 9047-9053.
Wong, C. F., C. Zheng, J. Shen, J. A. McCammon and P. G. Wolynes (1993). "Cytochrome c: a molecular proving ground for computer simulations." J. Phys. Chem. 97(13): 3100-3110.
Wong, C. F. and H. Rabitz (1991). "Sensitivity Analysis and Principal Component Analysis in Free Energy Calculations." J. Phys. Chem. 95(24): 9628-9630.
Wong, C. F. (1991). "Systematic Sensitivity Analyses in Free Energy Perturbation Calculations." J. Am. Chem. Soc. 113: 3208-3209.
Zheng, C., C. F. Wong and J. A. McCammon (1990). "Fluctuation of the solvent-accessible surface area of tuna ferrocytochrome c." Biopolymers 29: 1877-1883.
Shen, J., C. F. Wong and J. A. McCammon (1990). "Hydration of superoxide studied by molecular dynamics simulation." J. Comp. Chem. 11(8): 1003-1008.
Zheng, C., C. F. Wong, J. A. McCammon and P. G. Wolynes (1989). "Quantum Effects in Protein Dynamics." Chemica Scripta 29A: 171-179.
Wong, C. F., C. Zheng and J. A. McCammon (1989). "Glass transition in SPC/E water and in a protein solution: a molecular dynamics study." Chem. Phys. Lett. 154(2): 151-154.
Wong, C. F., J. Shen, C. Zheng, S. Subramaniam and J. A. McCammon (1989). "Molecular dynamics simulation of protein hydration: studies on tuna ferrocytochrome-c and bovine erythrocyte superoxide dismutase." J. Mol. Liq. 41: 193-206.
Shen, J., S. Subramaniam, C. F. Wong and J. A. McCammon (1989). "Superoxide dismutase: fluctuations in the structure and solvation of the active site channel studied by molecular dynamics simulation." Biopolymers 28: 2085-2096.
McCammon, J. A., C. F. Wong and T. P. Lybrand (1989). Protein Stability and Function: Theoretical Studies. Prediction of Protein Structure and Protein Conformation. G. D. Fasman. New York Plenum: 149-159.
Zheng, C., C. F. Wong, J. A. McCammon and P. G. Wolynes (1988). "Quantum simulation of ferrocytochrome c." Nature 334(6184): 726-728.
Wong, C. F. and J. A. McCammon (1988). Molecular Dynamics Simulation Studies of Water and Protein Solutions. Science on the ETA10. L. Anacker. Princeton, NJ, John von Neumann Center: 61-66.
McCammon, J. A., G. Ganti, T. P. Lybrand and C. F. Wong (1988). Supercomputer Simulation and Biomolecular Design. High Speed Computing, Scientific Applications and Algorithm Design. R. B. Wilhelmson, University of Illinois Press: 155-161.
Wong, C. F. and J. A. McCammon (1987). Protein-Water Surface Interactions: A Biomolecular Dynamics Simulation. Science at the John von Neumann Center, 1987. L. Anacker. Princeton, NJ John von Neumann Center: 131-134.
Wong, C. F. and J. A. McCammon (1986). "Computer simulation and the design of new biological molecules." Isr. J. Chem. 27: 211-215.
Wong, C. F. and J. A. McCammon (1986). Thermodynamics of Enzyme Folding and Activity: Theory and Experiment. Structure, Dynamics and Function of Biomolecules. A. Ehrenberg and R. Rigler. Berline, Springer-Verlag: 51-55.
Wong, C. F. and J. A. McCammon (1986). "Dynamics and design of enzymes and inhibitors." J. Am. Chem. Soc. 108(13): 3830-3832.