Professor Gokel attended Tulane and USC for BS and PhD degrees, respectively, and UCLA, where he was a postdoc with D.J. Cram. He was a faculty member at Penn State, Maryland, Miami and Washington University prior to joining UMSL as Distinguished Professor in 2006. He retired in 2021 and was appointed Distinguished Professor Emeritus. |
gokelg@umsl.edu |
Research Interests
Synthetic cation and anion channels
Mechanisms of Channel Formation and Biological Activity.
The compounds that have been designed, synthesized, and studied in the Gokel Lab are amphiphiles. These are compounds that have an affinity both for aqueous and for hydrocarbon environments. Lariat ethers, hydraphiles, and bis-tryptophans all fit this category and all of them form ion-conducting channels. Details of these and other synthetic ion channels are described in an article that may be found in Wikipedia. https://en.wikipedia.org/wiki/Synthetic_ion_channels.These synthetic ion channels enter membranes and conduct ions. They also increase membrane permeability in bacterial membranes and disrupt the function of efflux pumps. This allows them to function as antimicrobial agents and to enhance the potency of other antibiotics. Certain of the hydraphiles and bis-tryptophans are especially active (low nanomolar activity) against Gram negative, Gram positive, and even mycobacteria. We are currently exploring activity against hospital acquired pneumonia, a disease that has a high mortality rate in the US.
Selected Recent Publications
″Antimicrobial and Adjuvant Potencies of Di-n-alkyl Substituted Diazalariat Ethers″, M. B. Patel, H. Spikes, R. S. Bailey, T. Connell, H. Gill, M. R. Gokel, R. Harris, J. W. Meisel, S. Negin, S. W. Yin, and G. W. Gokel, Antibiotics, 2023, 12, 1513.
″Assessment of a host-guest interaction in a bilayer membrane model,″ H. Kumari, S. Negin, A. Eisenhart, M. B. Patel, T. L. Beck, F, Heinrich, H. J. Spikes, and G. W. Gokel, George. RSC Advances, 2022, 12, 32046.
″Crown ethers having side arms: a diverse and versatile supramolecular chemistry,″ M. R. Gokel, M. McKeever, J. W. Meisel, S. Negin, M. H. Patel, S. Yin and G. W. Gokel, J. Coord. Chem. 2021, 74, 14.
“Supramolecular pore formation as an antimicrobial strategy,“ H. Gill, M. R. Gokel, M. McKeever, S. Negin, M. H. Patel, S. Yin, and G. W. Gokel, Coord. Chem. Rev. 2020, 412, 213264
″Selective alteration of the root morphology of Arabidopsis thaliana by synthetic anion transporters (SATs)″, M. B. Patel, E. C. Garrad, S. Korb, S. Negin, M. R. Gokel, S. Sedinkin, S. Yin and G. W. Gokel, Chem. Sci. Int. J., 2019, 27, 1
″Synthetic ionophores as non-resistant antibiotic adjuvants,″ M. H. Patel, E. Garrad, J. W. Meisel, S. Negin, M. R. Gokel and G. W. Gokel, RSC Advances, 2019, 9, 2217.